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What Blood Tests Should You Get Every Year?

📅 Updated March 2026⏱️ 4 min read

TL;DR

A standard annual physical only checks the bare minimum required for insurance billing. To catch disease before it starts, you need a comprehensive baseline that includes fasting insulin, a full thyroid panel, ApoB, and inflammatory markers. Ask your doctor for these specific add-ons or use a direct-to-consumer lab service.

🔑 Key Findings

1

Standard lipid panels miss the mark; replacing LDL with ApoB gives a more accurate measure of cardiovascular risk.

2

Routine physicals check TSH but ignore Free T3 and Free T4, missing up to 7% of undiagnosed thyroid issues.

3

Fasting glucose only rises after years of metabolic dysfunction; checking fasting insulin catches insulin resistance up to a decade earlier.

4

Over 40% of American adults are vitamin D deficient, but this test is routinely skipped by basic insurance panels.

The Short Answer

Most doctors only order a CBC, a basic metabolic panel, and a standard lipid panel. This bare-minimum approach waits for you to get sick before sounding the alarm.

To actually monitor your health, you need to add specific longevity and metabolic markers. An optimal annual panel includes fasting insulin, a full thyroid panel, vitamin D, and inflammatory markers like CRP.

Why This Matters

The standard medical system operates on a "sick care" model, not a preventative one. Insurance companies dictate what your doctor can order, limiting tests to the absolute cheapest options.

By the time standard markers like fasting glucose go out of range, the damage is already done. Metabolic dysfunction develops for up to a decade before it shows up on a standard physical. What Is Fasting Insulin And Why Does It Matter

You don't have to settle for the standard insurance-approved panel. You can either demand specific add-ons from your primary care doctor or bypass them entirely using direct-to-consumer labs. What Are The Best Direct To Consumer Lab Testing Services

What's Actually In A Standard Panel

Your doctor's default blood work gives a decent high-level overview, but leaves massive blind spots. Here is exactly what your insurance covers during a routine physical.

  • Complete Blood Count (CBC) — Measures red cells, white cells, and platelets to check for basic infections or anemia. What Is A Cbc Blood Test
  • Comprehensive Metabolic Panel (CMP) — Looks at kidney function, liver enzymes, electrolytes, and basic blood sugar. What Is A Comprehensive Metabolic Panel
  • Standard Lipid Panel — Checks total cholesterol, LDL, HDL, and triglycerides, but misses advanced cardiovascular risk factors.
  • TSH (Thyroid Stimulating Hormone) — A surface-level check of thyroid function that misses autoimmune thyroid issues. What Thyroid Tests Should You Ask For

What to Look For

If you want to move from surviving to thriving, you need to request specific upgrades to your annual blood work. Ask your doctor for these proactive health markers to get a complete picture of your health. What Labs Should You Watch Closely

Green Flags (Must-Add Markers):

Red Flags (Why Standard Panels Fail):

  • "Normal" Range Reliance — Lab reference ranges are based on the average sick American, not optimal health.
  • Refusal to Test — If your doctor refuses to order basic preventative markers, it’s a sign they are bound by strict insurance guidelines.

The Best Options

If your doctor won't order a comprehensive panel, you can order it yourself. Direct-to-consumer testing is now cheaper and more accessible than ever. What Are The Best Direct To Consumer Lab Testing Services

BrandProductVerdictWhy
Function HealthFunction MembershipTests 100+ biomarkers, including all optimal add-ons, for under $500 a year. What Does Function Health Test For
Marek HealthCustom PanelLets you build an à la carte blood panel with no membership required.
Quest DiagnosticsStandard Physical⚠️Good for basic CBC/CMP, but you have to pay out of pocket for longevity markers.

The Bottom Line

1. Don't settle for the bare minimum. A standard physical is designed to catch late-stage disease, not optimize your health.

2. Ask for the metabolic and thyroid upgrades. Fasting insulin, ApoB, and a full thyroid panel are non-negotiable for a true health baseline. What Labs Should You Watch Closely

3. Bypass the middleman if needed. If your doctor says no, use a direct-to-consumer lab to get the data you deserve.

FAQ

Should women test their hormones annually?

Most standard physicals do not check sex hormones unless you report specific symptoms. Women dealing with fatigue, weight resistance, or mood changes should request a full hormone panel. Should Women Test Their Hormones

Does insurance cover advanced blood tests?

Usually, no. Insurance companies label preventative markers like fasting insulin and ApoB as "medically unnecessary." You will likely have to pay out of pocket or use a direct-to-consumer lab service.

How often should you get blood work done?

Once a year is the bare minimum for healthy adults. If you are actively trying to fix a deficiency, reverse insulin resistance, or optimize hormones, you should test every 3 to 6 months. How Often Should You Get Blood Work Done

🛒 Product Recommendations

Function Membership

Function Health

Tests 100+ biomarkers including everything missing from standard panels for a flat yearly fee.

Recommended

Custom Panel

Marek Health

Allows you to custom-build your own blood panel à la carte without a doctor's visit.

Recommended
⚠️

Standard Insurance Physical

Standard Care

Good for a basic baseline, but fails to check advanced markers for longevity and proactive health.

Use Caution

Base Test Kit

SiPhox Health

Uses silicon photonics technology to test 17 core longevity markers—including ApoB, fasting insulin, and ferritin—from a finger-prick sample at home. A 2024 review noted its results correlate well with standard venous draws for these specific lipid and metabolic markers.

Recommended

Ultimate Plan

InsideTracker

Tests 48 biomarkers including ApoB, insulin, and detailed iron/thyroid panels, then integrates with wearable data (Garmin/Apple Watch) to adjust lifestyle recommendations. Unlike standard labs, it flags 'optimal' ranges rather than just 'normal' disease ranges.

Recommended

Lifeforce Diagnostic

Lifeforce

A comprehensive intake panel that covers 50+ biomarkers, specifically targeting hormone optimization (free testosterone, IGF-1, DHEA-S) and metabolic health (ApoB, insulin). Includes a telehealth consult to interpret results, which is rare for direct-to-consumer labs.

Recommended
👌

Comprehensive Health Profile

Quest Diagnostics

One of the few direct-access panels from a major lab that actually includes fasting insulin, ApoB, and hs-CRP alongside the standard physical markers. Accessible at 2,000+ locations, though it requires a higher upfront payment than insurance-based testing.

Acceptable

Performance - Comprehensive Panel

Ulta Lab Tests

The best budget 'hack' for comprehensive testing; this bundled panel measures 40+ tests including insulin, CRP, and a full thyroid panel for often 50-70% less than list prices. Uses Quest Diagnostics facilities but bypasses the need for a doctor's requisition.

Recommended
👌

Heart Health Test

Verisana

A decent at-home option for basic cardiovascular screening (HbA1c, cholesterol, hs-CRP) if you cannot visit a lab. However, it lacks the crucial ApoB and fasting insulin markers found in more advanced panels like SiPhox.

Acceptable
🚫

Food Intolerance Test

Check My Body Health

Uses 'bioresonance' hair testing to claim sensitivity to 970+ items, a method completely lacking scientific validation. Allergy and immunology organizations state that hair cannot reveal food sensitivities or IgG antibodies.

Avoid
🚫

Wellness Cards

Vessel Health

Urine dipstick cards that claim to measure nutrient and hydration levels via a smartphone camera. User reviews and comparative tests consistently cite poor accuracy, with hydration scores often contradicting obvious physical signs.

Avoid
⚠️

At Home A1C Test Kit

CVS Health

Consumer reviews and validation studies report significant discrepancies between these at-home A1C results and laboratory blood draws. For a marker that dictates diabetes medication dosage, a 0.5-1.0% margin of error is clinically unacceptable.

Use Caution
⚠️
Full Body Intelligence

Viome

Uses proprietary RNA sequencing to analyze the microbiome but locks the raw data behind a 'black box' algorithm. Critics note the service functions largely as a funnel to sell expensive, personalized subscriptions for supplements and probiotics.

Use Caution
🚫

Genetic Nutrition Test

GenoPalate

Claims to prescribe a perfect diet based on DNA, but the science of nutrigenomics is not yet advanced enough to support such specific food recommendations. Most advice provided is generic healthy eating guidelines repackaged as 'genetic insights.'

Avoid
⚠️

Adrenal Stress Profile

ZRT Laboratory

Relying solely on saliva for hormone testing is controversial; while useful for cortisol patterns, it is less accurate than serum (blood) for thyroid and sex hormones. The 'adrenal fatigue' diagnosis often associated with these tests is not recognized by the Endocrine Society.

Use Caution
🚫

Food Sensitivity Test

YorkTest

Relies on IgG antibody testing, which measures food *exposure* rather than intolerance. High IgG levels often just mean you ate that food recently, leading to unnecessary restrictive diets and false alarm.

Avoid
⚠️

Mental Vitality DX

EmpowerDX

Customer reports frequently cite 'Test Not Performed' (TNP) errors due to sample stability issues during shipping. The panel combines standard markers (B12, Vitamin D) with genetic markers (MTHFR) that are better tested separately.

Use Caution

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